Understanding host-pathogen interaction in malaria parasite invasion of red blood cells

Malaria parasites captured invading a red blood cell
A red blood cell (magenta) is being invaded by two malaria parasites (cyan), where each parasite wraps itself with the red blood cell membrane to form a ‘pocket’ in which it will grow and replicate. Credit: Ms Cindy Evelyn and Dr Niall Geoghegan, Rogers Laboratory

How malaria parasites break into red blood cells  

Unlike many other cells, the red blood cell is not endocytic, meaning that it does not have a natural way for bringing in material from the outside environment.

Infectious diseases

Understanding how cancer cells spread

A blood vessel network in lung tissue appears as a tree-like structure is shown in orange against a pink and dark background
This tree-like structure is the complicated blood vessel network present in lung tissue. Ms Lewis is exploring new methods that enable cancer researchers to accurately pinpoint the location of cancer cells as they spread. Image: Sabrina Lewis

Cancer cell diversity affects efficacy of cancer therapy

Tumours are diverse tissue structures – this means they are composed of many different cell types (cancerous and non-cancerous cells).

Cancer

Observations of phase changes in monoolein during high viscous injection

Wells DJ, Berntsen P, Balaur E, Kewish CM, Adams P, Boutet S, Broomhall H, Caleman C, Christofferson A, Conn CE, Dahlqvist C, Flueckiger L, Gian Roque F, Greaves T, Hejazian M, Hunter M, Hadian Jazi Marjan, Jonsson HO, Pathirannahalage SK, Kirian R, Kozlov A, Kurta R, Marman H, Mendez D, Morgan A, Nugent K, Oberthuer D, Quinney H, Reinhardt J, Saha S, Selberg J, Sierra R, Wiedorn M, Abbey B, Andrew M, Darmanin C. Observations of phase changes in monoolein during high viscous injection. J Synchrotron Radiat. 2022 May 1;29(Pt 3). PMID: 35510993

PMID Link
J Synchrotron Radiat. 2022

Data reduction for serial crystallography using a robust peak finder

Marjan Hadian-Jazi, Alireza Sadri, Anton Barty, Oleksandr Yefanov, Marina Galchenkova, Dominik Oberthuer, Dana Komadina, Wolfgang Brehm, Henry Kirkwood, Grant Mills, Raphael de Wijn, Romain Letrun, Marco Kloos, Mohammad Vakili, Luca Gelisio, Connie Darmanin, Adrian P Mancuso, Henry N Chapman, Brian Abbey. Data reduction for serial crystallography using a robust peak finder. J Appl Crystallogr. 2021 Sep 13;54(Pt 5):1360-1378. PMID: 34667447

PMID Link
J Appl Crystallogr. 2021.

Clathrin and GRK2/3 inhibitors block δ-opioid receptor internalization in myenteric neurons and inhibit neuromuscular transmission in the mouse colon

Jesse J DiCello, Pradeep Rajasekhar, Emily M Eriksson, Ayame Saito, Arisbel B Gondin, Nicholas A Veldhuis, Meritxell Canals, Simona E Carbone, Daniel P Poole. Clathrin and GRK2/3 inhibitors block δ-opioid receptor internalization in myenteric neurons and inhibit neuromuscular transmission in the mouse colon. Am J Physiol Gastrointest Liver Physiol. 2020. PMID: 31091149

PMID Link
Am J Physiol Gastrointest Liver Physiol, 2020.
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