McArthur K, Whitehead LW, Heddleston JM, Li L, Padman BS, Oorschot V, Geoghegan ND, Chappaz S, Davidson S, San Chin H, Lane RM, Dramicanin M, Saunders TL, Sugiana C, Lessene R, Osellame LD, Chew TL, Dewson G, Lazarou M, Ramm G, Lessene G, Ryan MT, Rogers KL, van Delft MF, Kile BT. Science. 2018 2018 Feb 23; 359 (883). doi: 10.1126/science.aao6047 PMID: 29472455
Our work
The Centre for Dynamic Imaging is helping researchers make exciting discoveries impacting major areas of human health.
Visualising biological mechanisms and behaviours is a gateway to understanding disease.
Scientists are now capturing spectacular images and real-time video from single cells and tissue slices, right through to whole organs. These new views of biology are bringing us closer to developing better disease diagnostics and treatments
A red blood cell (magenta) is being invaded by two malaria parasites (cyan), where each parasite wraps itself with the red blood cell membrane to form a ‘pocket’ in which it will grow and replicate. Credit: Ms Cindy Evelyn and Dr Niall Geoghegan, Rogers Laboratory
This tree-like structure is the complicated blood vessel network present in lung tissue. Ms Lewis is exploring new methods that enable cancer researchers to accurately pinpoint the location of cancer cells as they spread. Image: Sabrina Lewis
Cells dying by necroptosis, an inflammatory form of cell death which is driven by the protein MLKL
Image of a lung in its very early stages of development. As it grows, the lung’s ‘roots’ thin and multiply into the intricate airway structures that form an adult lung. Credit: Casey Ah-Cann
Magnified snapshot of a mammary gland during lactation. In yellow are muscle cells that contract and release, helping to squeeze milk into the mammary ducts. Purple flecks in and around the structures are immune cells on high alert for any threats in order to help keep the breast tissue healthy. Credit: Caleb Dawson
Imaging of the retinal vasculature is used to study various eye diseases and conditions. Here cells within the minor vasculature are segmented while the main vessels are excluded. Credit: Emma Watson, Leigh Coultas, Lachlan Whitehead
Mitochondrial DNA release during cell death, captured on the lattice light sheet. Credit: Kate McArthur, Niall Geoghegan
SIM (structural illumination microscopy) image of SMCHD1 in the nucleus, captured using Deltavision OMX SR. Credit: Iromi Wanigasuriya
Long term imaging of cancer cells. Credit: Dr Kim Pham
A group of red blood cells (magenta) with the central cell infected by P.falciparum, the parasite that causes the deadliest form of malaria. Credit: Dr Michał Pasternak
Selected Publications
BAK/BAX macropores facilitate mitochondrial herniation and mtDNA efflux during apoptosis.
Endothelial cell survival during angiogenesis requires the pro-survival protein MCL1
Watson EC, Whitehead L, Adams RH, Dewson G, Coultas L. Endothelial cell survival during angiogenesis requires the pro-survival protein MCL1. Cell Death Differ. 2016 Aug;23(8):1371-9. doi: 10.1038/cdd.2016.20. Epub 2016 Mar 4. PubMed PMID: 26943318
Essential Role of the PfRh5/PfRipr/CyRPA Complex during Plasmodium falciparum Invasion of Erythrocytes
Volz JC, Yap A, Sisquella X, Thompson JK, Lim NT, Whitehead LW, Chen L, Lampe M, Tham WH, Wilson D, Nebl T, Marapana D, Triglia T, Wong W, Rogers KL, Cowman AF. Essential Role of the PfRh5/PfRipr/CyRPA Complex during Plasmodium falciparum Invasion of Erythrocytes. Cell Host Microbe. 2016 Jul 13;20(1):60-71. doi:10.1016/j.chom.2016.06.004. Epub 2016 Jun 30. PMID: 27374406
EGF-mediated induction of Mcl-1 at the switch to lactation is essential for alveolar cell survival
Fu NY, Rios AC, Pal B, Soetanto R, Lun AT, Liu K, Beck T, Best SA, Vaillant F, Bouillet P, Strasser A, Preiss T, Smyth GK, Lindeman GJ, Visvader JE. EGF-mediated induction of Mcl-1 at the switch to lactation is essential for alveolar cell survival. Nat Cell Biol. 2015 Apr;17(4):365-75. doi: 10.1038/ncb3117. Epub 2015 Mar 2. PubMed PMID: 2573047
T cell signaling. Antigen affinity, costimulation, and cytokine inputs sum linearly to amplify T cell expansion
Marchingo JM, Kan A, Sutherland RM, Duffy KR, Wellard CJ, Belz GT, Lew AM, Dowling MR, Heinzel S, Hodgkin PD. T cell signaling. Antigen affinity, costimulation, and cytokine inputs sum linearly to amplify T cell expansion. Science. 2014 Nov 28;346(6213):1123-7. doi: 10.1126/science.1260044. PMID: 25430770
In situ identification of bipotent stem cells in the mammary gland
Rios AC, Fu NY, Lindeman GJ, Visvader JE. In situ identification of bipotent stem cells in the mammary gland. Nature. 2014 Feb 20;506(7488):322-7. doi: 10.1038/nature12948. Epub 2014 Jan 26. PMID: 24463516
A lineage of diploid platelet-forming cells precedes polyploid megakaryocyte formation in the mouse embryo
Potts KS, Sargeant TJ, Markham JF, Shi W, Biben C, Josefsson EC, Whitehead LW, Rogers KL, Liakhovitskaia A, Smyth GK, Kile BT, Medvinsky A, Alexander WS, Hilton DJ, Taoudi S. A lineage of diploid platelet-forming cells precedes polyploid megakaryocyte formation in the mouse embryo. Blood. 2014 Oct 23;124(17):2725-9. doi: 10.1182/blood-2014-02-559468. Epub 2014 Jul 25. PMID: 25079356
Cell-cell communication between malaria-infected red blood cells via exosome-like vesicles
Regev-Rudzki N, Wilson DW, Carvalho TG, Sisquella X, Coleman BM, Rug M, Bursac D, Angrisano F, Gee M, Hill AF, Baum J, Cowman AF. Cell-cell communication between malaria-infected red blood cells via exosome-like vesicles. Cell. 2013 May 23;153(5):1120-33. doi: 10.1016/j.cell.2013.04.029. Epub 2013 May 15. PMID: 23683579
Spatial association with PTEX complexes defines regions for effector export into Plasmodium falciparum-infected erythrocytes
Riglar DT, Rogers KL, Hanssen E, Turnbull L, Bullen HE, Charnaud SC, Przyborski J, Gilson PR, Whitchurch CB, Crabb BS, Baum J, Cowman AF. Spatial association with PTEX complexes defines regions for effector export into Plasmodium falciparum-infected erythrocytes. Nat Commun. 2013 4:1415. doi:10.1038/ncomms2449. PubMed PMID: 23361006; PubMed Central PMCID: PMC3562467
Activation-induced B cell fates are selected by intracellular stochastic competition
Duffy KR, Wellard CJ, Markham JF, Zhou JH, Holmberg R, Hawkins ED, Hasbold J, Dowling MR, Hodgkin PD. Activation-induced B cell fates are selected by intracellular stochastic competition. Science. 2012 Jan 20;335(6066):338-41. doi: 10.1126/science.1213230. Epub 2012 Jan 5. PMID: 22223740